Are you one of the millions of diabetics worldwide who must endure multiple painful daily insulin injections? Maybe you have considered other therapies such as an insulin pump but were intimidated by the somewhat invasive procedure. What if there was a way for you to restore your body’s ability to produce insulin using your very own cells? This is the basis of a revolutionary new therapy called “autologous cell replacement” therapy that is being studied by researchers at a small biotech company named Orgenesis.
The fundamental process of ACR therapy is the harvesting of one’s own stem cells and re-implanting them, in order to regenerate functional adult cells; in this case, the intent is to regenerate cells that are capable of producing insulin. The first step is to extract healthy liver cells via a standard liver biopsy. These cells are then sent to a lab where they are carefully separated, and a portion of them are manipulated using a therapeutic agent known as PDX-1. This “master regulator” oversees pancreatic development and can be used to transform a portion of your liver cells into “autologous insulin producing” cells that function similarly to beta cells, which normally produce insulin in the pancreas of healthy people.
In addition to producing insulin, these new AIP cells are also capable of storing and secreting insulin in a glucose-regulated manner. These cells are then transplanted back into the patient’s liver where they will continue to produce insulin; because they were originally produced by the patient, there is no risk of rejection. Your liver would now serve a dual-purpose by continuing to work in the normal metabolic function yet produce insulin as well.
The use of PDX-1 to change the function of liver cells has been shown to be successful in mice using recombinant adenovirus gene therapy, and researchers are currently working to initiate the first clinical trial for human patients. You may have heard on the news of the controversy surrounding stem-cell therapy, but that is the great feature of ACR therapy: you are using your own stem cells to treat your own disease. This eliminates the need for organ donation as well as embryo-derived stem cells.
The benefits from this therapy would be significant, as patients would be able to eliminate multiple daily injections, rigid dietary restrictions and regimented exercise plans. While the progress being made at Orgenesis is truly remarkable, it must be realized that the therapy is years away from being a viable option. Until the day comes when ACR therapy is the first treatment option for diabetics, the people at Focus Express Mail Pharmacy are here to help you receive all your current diabetic supplies at no out-of-pocket cost. With over 20 years of experience in all diabetic therapies, Focus Express Mail Pharmacy will no doubt be pioneering new and exciting therapies such as ACR to all those who suffer from diabetes.