Gallstones Caused by Insulin Resistance in People with Diabetes
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Researchers at the Joslin Diabetes Center have determined that insulin resistance is likely the reason why gallstones are more common in obese people. Sudha Biddinger, M.D., Ph.D., lead author of the study and a researcher in the Joslin Section on Obesity and Hormone Action, said:
"Obesity is associated with increased secretion of cholesterol into the bile. The excess cholesterol accumulates in the gallbladder which can lead to the formation of painful gallstones. This study shows that insulin resistance is key to this process, as the lack of insulin receptors in the livers (of research mice) was sufficient to promote gallstones".
