HDAC Enzyme Suppression May Lead to New Drug for Diabetes
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Researchers at the Salk Institute have recently discovered that the liver enzyme HDAC stimulates the production of glucose. In a series of trials performed on four different types of mice, scientists have found a way to suppress liver HDAC (histone deacetylases) which will hopefully lead to trials on humans.
"The discovery of HDAC (histone deacetylases) in the liver could have a major impact on the discovery of new compounds for the treatment of diabetes," said Robert Henry, president for science and medicine at the American Diabetes Association. "A new class of drugs that are specific inhibitors of HDAC would target the excess production of glucose by the liver which is a major contributor to high glucose levels in diabetes."
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