Diabetes Pharmacist : Diabetes Pharmacist Blog : Focus Express Mail Pharmacy : Insulin Pumps, Diabetes Supplies and Information

A recent study has demonstrated that giving mice a combination of low doses of Metformin (brand name Gluophage)  with the common chemotherapy medication Doxorubicin (brand name Adriamycin) shrank breast-cancer tumors and prevented their recurrence more effectively than chemotherapy alone.

Chemotherapy is effective against many tumors, said Kevin Struhl, a Harvard Medical School researcher and principal investigator of the study. "The problem is cancer stem cells acquire resistance" to treatment, he said. "They are able to regenerate the tumor and as a result you end up with a relapse."

Researchers said the combination of metformin and doxorubicin killed both regular cancer cells and cancer stem cells. In contrast, doxorubicin alone had limited effect on the stem cells.

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A new drug  for both Type 1 and Type II diabetes,called Exsulin, is in the "pipeline" and could be sent to the FDA for approval in a few years.  Alexander Fleming, MD, former US Food and Drug Administration official and Exsulin Corp. Chief Medical Officer, said "the drug causes the cells in the pancreas to develop into insulin-secreting cells.This is actually a natural hormone we’re developing as a therapy.”  Exsulin will be injected like insulin, but it won't have any direct effect on blood sugar. 

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